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GLUTATHIONE BACKGROUND

IMPORTANCE IV

GSH levels decrease with age (1% per year).

Age matched normals reveal those with any defined disease have decreased GSH compared to "well" subjects.

GSH is major protector of Mitochondrial DNA (MtDNA). Compared to 5 year olds, only 5% of MtDNA is normal in 90 year olds.

Maintenance of normal MtDNA directly correlates with maximum life span Centenarians demonstrate GSH levels similar to 30-50 year old well normals.

Caloric restriction (animals) increases GSH and SIRT1.

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7 of 14 Slides

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