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GLUTATHIONE BACKGROUND
IMPORTANCE IV
GSH levels decrease with age (1% per year).
Age matched normals reveal those with any defined disease have decreased GSH compared to "well" subjects.
GSH is major protector of Mitochondrial DNA (MtDNA). Compared to 5 year olds, only 5% of MtDNA is normal in 90 year olds.
Maintenance of normal MtDNA directly correlates with maximum life span Centenarians demonstrate GSH levels similar to 30-50 year old well normals.
Caloric restriction (animals) increases GSH and SIRT1.
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